|
KMID : 0362720160540040284
|
|
Journal of the Korean Dental Association
2016 Volume.54 No. 4 p.284 ~ p.295
|
|
|
Effect of Epigallocatechin-3-Gallate on the alveolar bone remodeling and arthritis in collagen-induced arthritis model in mice
|
|
조인우:Cho In-Woo
임성준:Yim Seong-Jun/신현승:Shin Hyun-Seung/박정철:Park Jung-Chul/:Equal contribution
|
|
|
Abstract
|
|
|
|
The aim of this study was to evaluate the effect of Epigallocatechin-3-Gallate (EGCG) on the alveolar bone metabolism in a collagen-induced arthritis (CIA) model in mice to enhance the understanding of rheumatoid arthritis (RA)-associated alveolar bone loss. Following the induction of CIA in animals (mice, n=16), mandibles were retrieved for micro-computed tomography (micro-CT) and isolation of alveolar bone cells (ABCs). In vitro osteogenic potentials of ABCs were evaluated and the mRNA expression of downstream effector genes was assessed. CIA was successfully induced in all animals, and micro-CT data showed that alveolar bone loss was significantly increased in the CIA group while the treatment of EGCG prevented the alveolar bone resorption. Osteogenesis by ABCs was significantly increased in the CIA+EGCG group in vitro. The analysis of mRNA expressions showed that osteoclastogenesis-associated genes were increased in CIA group while bone protecting genes were upregulated in EGCG treated group. The results demonstrate that EGCG downregulated the alveolar bone resorption in a CIA model in mice, and upregulation of bone protecting genes appear to be involved. Further studies are warranted.
|
|
|
KEYWORD
|
|
|
Rheumatoid Arthritis, Periodontitis, Epigallocatechin-3-Gallate (EGCG)
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|